The game starts with Zagreus, son of Hades who is desperately trying to fight through Hades (the place) to escape. He has just found out that his biological mother is somewhere out there. He is done living under the tyranny and abuse of his father and wants out. After fighting through a few levels of Tartarus, he eventually falters and is slain by something or other. Zagreus comes to in a giant pool of blood which he wades his way out of. He is reborn and he has been returned to the house of Hades. It is here that you will be returned whenever you die while playing the game. It is a hub that contains the receiving hall for the dead where they are judged and sent to their eternal reward. It also contains Agreus’ bedroom and armory where he can regroup before another run at escaping.

That cycle is the crux of the game. Agreus sneaks out of his room and tries to escape. During a run, Agreus fights through as many levels as he can toward freedom. The run always starts with Zagreus jumping out of a window behind his bedroom. He lands in Tartarus, a harsh place where souls who have sinned and/or committed crimes are sent and imprisoned. This is an early area allowing Zagreus to slowly build his power. It is the easiest place in the game. The River Styx ends in Tartarus (actually in the pool that Zagreus emerges from each time he dies).
The second area he arrives at is Asphodel. It was once called the Asphodel Meadows where souls that were unremarkable in life were sent. It has since been flooded by the river Phlegethon turning it into small islands separated by boiling hot lava. Here, the terrain is very dangerous, making it hard to fight in closer quarters. It slowly teaches Zagreus how to fight with more precision. Of course, the lava can also hurt enemies so learning how to use the environment can be very beneficial. This area's exit is guarded by the Lernean Bone Hydra who Zagreus eventually nicknames Lernie.
The third area is Elysium. This is where the glorious dead go when they die. Note that the dead in Elysium are often not sinless but they are the most beloved of the Gods. This is where heroes and kings go when they die (as long as they don’t piss off the Gods). The area is beautiful with stone statues representing heroes past and everything is overgrown with greenery. The river Lethe drifts through this section and its waters help the dead forget their pain.
The fourth area is the Temple of Styx. This is the gateway between the land of the living and the dead. It was once a temple operated by humans but they were probably scared off by Cerberus long ago. Instead, the labyrinthine building is full of rats and satyrs. The infestation is bad and Zagreus must manage them to get through the Temple. As the name suggests, this is very near the headwaters of the River Styx which flows all the way back to the House of Hades.
The final area is Greece. If Zagreus makes it through all four areas of Hades, he can emerge in the human world. Greece is very pretty but it is also experiencing a rather harsh winter. Not much is seen of it but once can assume that it is much like our Ancient Greece.
The other part of the cycle of the game is socialization. Zagreus feels like he is alone in his escape attempts but nothing could be farther from the truth. Each time he dies (and somewhat during the run) he has the ability to talk to other characters. If he can gain their favor, they may make things a little easier for Zagreus during subsequent escape attempts. They usually provide trinkets and/or boons that help Zagreus temporarily power up. So let’s meet the characters, starting with the Household of Hades.

Nyx
The Chthonic Goddess of the Night and co-ruler of Hades. She is a primordial God who was there at the very beginning of things. Due to her domain being night and darkness, many people rightfully fear her. However, she has always acted very maternal toward Zagreus as a sort of foster mother. While Hades treated his son with disdain, Nyx always supported him. In fact, it was Nyx who carefully arranged certain aspects of Zagreus’ repeated escape attempts. She gives him counsel and also the Mirror of Night which allows him to collect darkness to be used to permanently increase his skills and abilities. She manages the household with a cold, detached demeanor even with her own numerous children.
Hypnos
The youngest of Nyx’s children seen in the game. He is tasked with keeping the line of souls waiting to be judged by Hades moving and recording how each person died. However, Hypnos is rather lazy and spacy and is often found asleep on the job. He is nice enough but is way over his head and definitely not really suited for hard work. When Zagreus dies and is reborn, he often jovially remark on how Zagreus died. Despite his good humor, he does not get along with the rest of his family or Hades because of his laziness.
Thanatos
One of Nyx’s children and an older twin brother to Hypnos. He is the personification of death and is sent out into the human world to bring back those who have died. He is an expert combatant and wields his scythe with such precision that those he kills feel no pain. It is just that quick. He has a prickly demeanor that comes off as terse or harsh but is a softy under the surface. He is a workaholic, endlessly toiling at retrieving the dead. Thanatos is a beautiful man and it is an open secret that he has feelings for Zagreus, one of the few people to worm their way past his defenses. He is one of two characters that Zagreus can start a romantic relationship with. Randomly, Thanatos can appear during an escape run. He appears out of thin air and challenges Zagreus to see who can kill the most enemies. This is his way of helping Zagreus escape.
Charon
Brother to Thanatos and Hypnos and son of Nyx. He is the boatman who ferries souls on the River Styx to the House of Hades. He speaks no words but communicates his feelings through groans and grunts. He is mysterious and many other characters can only guess at his motivations and thoughts. He can only be met during an escape run in chambers where he has come ashore. His boat can be seen as he stands on the shore, holding his oar like a scepter. He independently has decided to help Zagreus by selling him boons and items that he has collected for Obols. It is possible to try and steal Obols from him but he will retaliate by pulling Zagreus into Erebus (a secret area) to engage him in combat. Charon is very formidable at combat.
Megaera
One of the three Fury Sisters. As with her sisters, she is tasked with punishing the dead in Tartarus and with preventing the dead from trying to escape Tartarus. She is one of three possible bosses that Zagreus must defeat to escape Tartarus. She is the most reasonable of her sisters and treats her duties as just a job. However, she has a special hatred for oath-breakers. She and Zagreus used to date and after socializing with her a bit, she comes to collect her stuff from Zagreus’ bedroom. It is possible for Zagreus to rekindle their romance. If he establishes a romance or friendship with Meg, she will still try and prevent him from escaping. Trying to kill each other is just business. It is actually possible to enter a throuple with both Megaera and Thanatos.
Alecto
One of the three Fury Sisters. She is also tasked with punishing the dead in Tartarus and preventing escape. She is also one of three possible bosses Zagreus needs to defeat to get out of Tartarus. Her specialty is punishing those who allowed their passions to cause them to commit heinous acts. She is very passionate about her job and gains sadistic delight in making Zagreus bleed, nicknaming him “Red Blood” since that is a rarity in Hades. Unlike Megaera, she is not allowed into the House of Hades due to her antisocial behavior. Therefore, she can not be socialized with outside of trash talk before combat.
Tisiphone
The third Fury Sister. She is also tasked with punishing the dead in Tartarus and preventing escape. She is also one of three possible bosses Zagreus needs to defeat to get out of Tartarus. Her specialty is punishing murderers. Her job has definitely caused her to snap and she is no longer capable of coherent speech outside of the words “murder” and “murderer”. However, she does learn to say “Zagreus” if he kills her enough times. Unlike Megaera, she is not allowed into the House of Hades due to her antisocial behavior. Therefore, she can not be socialized with outside of trash talk before combat.
Dusa
As her name and appearance may have indicated, Dusa is a gorgon. In the world of the game, gorgons are able to hide their bodies and allow their heads to levitate around. She is the household’s Chief Custodian and tirelessly works to keep up with the cleaning and repair of the House of Hades. She is ceaselessly chipper and if she has a fault, it is that she works way too hard. She is very shy and often levitates up into the rafters if Zagreus is able to try to talk to her. Over time, she manages to learn to slow down and also forms a genuine friendship with both Zagreus and Megaera. She is Zagreus’ biggest fan and cheerleader.
Skelly
A “bloodless” who Zagreus encounters in the training area attached to his bedroom. Skelly is a sarcastic yet friendly guy. He is tasked with being Zagreus’ training dummy. He does not seem to be hurt too much by it and when he dies, he just resurrects again. Surprisingly, it is revealed that he is not on the payroll of the House of Hades and nobody knows who hired him. He knows a lot about the weapons that Zagreus can unlock.